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Note: Other medications can affect how Sildenafil is processed in your body, potentially impacting its effectiveness. These include azole antifungals (such as itraconazole or ketoconazole), macrolide antibiotics (such as clarithromycin or erythromycin), HIV protease inhibitors (such as saquinavir), mifepristone, rifampin, and ritonavir.

Combining Sildenafil with other medications for erectile dysfunction (ED) or pulmonary hypertension, such as tadalafil or vardenafil, is harmful.

***** Interactions with other medications

intakes of other medications will not be responsible for those interactions. Keep a list of all the medications you are currently starting with a variety of interactions to see the best deal for your health needs (or, more specifically, your lifestyle).

Increased blood pressure may be accompanied by dizziness, fainting, or blurred vision

Alcohol can amplify the effects of Sildenafil, so limit your alcohol consumption to less than 1 pack of four times a day.

Grapefruit juice and added sugar can increase the blood pressure-lowering effects of Sildenafil. Watch for hypoglycemia or overt hypoglycemia if you are using Sildenafil to treat ED or risk an dangerous drop in blood sugar levels.

untsifide inhibitor drugUGT69 inhibitorHIV protease inhibitorPimozide or medicines such as indinavir or ketoconazole

Avoid using Sildenafil with these medications: ritonavir, saquinavir, fosamprenavir or indinavir

High blood pressure treatment medication indiferentiated by insuranceADVIN or Medicare Advantage

Alcohol and high blood pressureUsing Sildenafil with other medications that may interact with SildenafilThe list of medications that may interact with Sildenafil is long list use, so this list is not exhaustive.

Some alcohol or food products, such as grapefruit juice, avoid Sildenafil as they may increase its effectiveness.

Avoid consuming excessive alcohol or combining medications that increase Sildenafil levels with Sildenafil.

Sudden vision loss

Stop using this product and call the doctor for medical advice about what you are taking. You may experience a sudden decrease or loss of vision.

Possible side effects

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Other ingredientssuch as carbun},{"[UNURBSort]

Sildenafil 20mg+Each gram of Sildenafil has a distinct specific full composition - Sildenafil is in a form that your body can produce and in which you take it.

Vision changes

Some side effects may occur but not every potential case. Call your doctor for medical advice about side effects. You may experience loss of vision or hearing. Rarely, sudden decreased vision or hearing.

Vision changes can be dangerous. Your doctor will start you on a case by case basis and adjust your dose depending on your risk for sudden vision loss.

Note: Other medications can affect how Sildenafil is processed in your body, potentially impacting its effectiveness. These include azole antifungals (such as itraconazole or ketoconazole), macrolide antibiotics (such as clarithromycin or erythromycin), HIV protease inhibitors (such as saquinavir), mifepristone, rifampin, and ritonavir.

Combining Sildenafil with other medications for erectile dysfunction (ED) or pulmonary hypertension, such as tadalafil or vardenafil, is harmful.

***** Staxyn*****azarherbalLifestyleConsiderations:***** Medications with a narrow range of activity in the same family of medications may interact with Sildenafil, so their interactions may more than likely occur independently. Before using Sildenafil, you should talk to your doctor about your options.
  • Avoid using Sildenafil with nitrates used for treating chest pain.
  • If you’re also taking an alpha-blocker for an enlarged prostate (like doxazosin or tamsulosin), it causes a lower blood pressure level, leading to dizziness or fainting. This common side effect is usually mild.
  • If you’re also taking an alpha-blocker for an enlarged prostate (like tamsulosin or doxazosin), it can cause dizziness or fainting. A lower dose of Sildenafil prescribed by the doctor also helps.
  • Grapefruit and grapefruit juice can both increase Sildenafil's effectiveness. Avoid using these products with grapefruit juice, as they can increase Sildenafil’s risk of side effects.

    Large intestine effects can be minimised by using a lower dose of Sildenafil. If you’re taking an oral rehydrationing (OR) medication, such as R-27,5-cholocetacid, you should avoid using Sildenafil with an OR instead.

    Vacant and prescription medications have been shown to interact with Sildenafil, which can mean it is more effective for some conditions. Always inform your doctor about your medications before starting Sildenafil.

    All available data

    Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor. PDE5 is a naturally occurring enzyme which breaks down cGMP, the substance in the body. cGMP is known as the cyclic guanosine monophosphate (cGMP) signal.

    Sildenafil PDE5 is primarily in the smooth muscle cells of the penis. It helps relax the muscles surrounding the blood vessels of the penis, allowing them to become more bloodolved. Sildenafil can also help increase blood flow to the penis, facilitating an erection when the medication is taken.

    Sildenafil PDE5 is known as a PDE5 inhibitor because it breaks down cGMP. This cGMP is then taken by the cells to broken down.

    Sildenafil has a molecular weight of 213.5. Sildenafil has a molecular weight ofetermination of itraconazole of 53.

    Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

    Dosage and Administration

    Sildenafil is available in 25mg, 50mg, and 100mg strengths.

    • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
    • Dosage can be adjusted depending on individual response and tolerability.
    • Take only one tablet in 24 hours, with or without food.
    • Avoid grapefruit juice, as it can increase the risk of side effects.
    • A high-fat meal may delay onset of action.

    Effectiveness

    Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

    Side Effects

    Common side effects include:

    • Headache
    • Flushing
    • Nasal congestion
    • Indigestion

    Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

    Contraindications

    Sildenafil should not be used by those:

    • Taking nitrates for chest pain
    • With severe heart or liver conditions
    • Under 18 years of age
    • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

    Interactions

    Inform your doctor of all medications and supplements before use. Interactions may occur with:

    • Nitrates
    • Alpha-blockers
    • Some antibiotics and antifungal medicines

    Alcohol and Heart Conditions

    Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

    Availability and Cost

    Sildenafil is available by prescription only in the UK.

    • Generic versions are more affordable than branded Viagra.
    • Supplied by licensed UK pharmacies such as Online Chemist.
    • Avoid counterfeit products from unregulated websites.

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    • Mental problems

    Less common side effects and serious side effects include:

    • Severe allergic reactions
    • Trouble speaking
    • Shortness of breath
    • Changes to hearing
    • Severe headache

    Hussain Sinh, Mabial Herat, Abdelhattarsaddar Khan, et al. Side Effects and reports of sildenafil‑associated diabetic ketoacidosis. Int J Pharm Biomed Pharm S 2024;35:1.

    Price and Availability

    Dr Fox supplies affordable generic sildenafil in the UK, and prices are the subject of genuine orders only.

    Uses of Sildenafil

    Sildenafil is used to treat pulmonary arterial hypertension and to improve penile functions.

    Therapeutic Category

    Sildenafil: Phosphodiesterase type 5 (PDE 5) inhibitors

    How Sildenafil works

    Sildenafil works by blocking the effects of certain enzymes (PDE5) within the body which limits blood flow to the lungs and penis. As a result, it causes widening of blood vessels (arteries) supplying these organs, increases blood flow and oxygen supply and improves their functions.

    Common side effects of Sildenafil

    • headache
    • flushing
    • indigestion, diarrhoea
    • pain in the arms or legs
    • vision problems
    • flu-like symptoms, inflammation of the sinuses, fluid retention
    • difficulty in sleeping, anxiety, shaking
    • sensation of pins and needles
    • vertigo (spinning sensation)
    • nosebleed, runny nose, cough, stuffy nose
    • nausea, vomiting, stomach inflammation, heartburn, piles, abdominal distension, dry mouth, diarrhea
    • hair loss
    • skin redness, night sweats
    • muscle pain, back pain
    • increased erections

    When to consult your doctor

    Consult your doctor if you experience:

    • prolonged or painful erection (priapism)
    • sudden decline or loss of vision
    • fits or seizures
    • pneumonia, abnormal heartbeat, chest pain, fainting
    • infections (viral infection of the gut, urinary tract infections and tooth cavities)
    • fits, hearing impairment inflammation of digestive tract

    Health Tips for Sildenafil

    • Sildenafil is not suitable for use in women
    • Sildenafil is generally more effective when taken on an empty stomach
    • Avoid consumption of alcohol or grapefruit juice while taking Sildenafil as it may increase its side effects
    • Avoid using recreational drugs (like amyl nitrate, etc.) while taking sildenafil as it may cause a dangerous drop in blood pressure
    • Sildenafil should not be taken more than once in a 24-hour period
    • Before taking Sildenafil, inform your doctor if you have any liver, kidney, or heart problems
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    Use of Sildenafil in pregnancy and while breastfeeding

    Sildenafil is not recommended for use in infants or children less than 17 years.

    Potential side effects of Sildenafil

    Do not take Sildenafil if you:

    • Take any medication containing nitrates (used to treat angina or chest pain)
    • Have or have had any health problems affecting the liver or the kidneys

    Sildenafil should not be taken if you have any of the following health problems:

    • Heart attack, stroke or briefing (e.g. IUD)
    • Long QT syndrome
    • ystemic retention (hearing loss, seizures, fits, etc)
    • Kidney disease
    • Dementia.
    • Enlarged prostate
    • Dehydration
    • High levels of blood glucose in the urine

    For the health condition you are taking sildenafil, information on or other effective coping measures should be readily available on.

    Note: Other medications can affect how Sildenafil is processed in your body, potentially impacting its effectiveness. These include azole antifungals (such as itraconazole or ketoconazole), macrolide antibiotics (such as clarithromycin or erythromycin), HIV protease inhibitors (such as saquinavir), mifepristone, rifampin, and ritonavir.

    Combining Sildenafil with other medications for erectile dysfunction (ED) or pulmonary hypertension, such as tadalafil or vardenafil, is harmful.

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    Viagra was the first drug to hit the US market, and a new generation of drugs is taking the market by storm.

    Viagra, made by Pfizer Inc., was the most-prescribed drug in America in the first half of 2019. The company's top-selling prescription drug, sildenafil, is now the company's biggest seller in the United States.

    Sildenafil, also known as Viagra, was the most-prescribed drug in America in 2019. Viagra, made by Pfizer Inc., is the drug company's largest seller, and it is expected to sell nearly 200 million prescriptions annually.

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    In contrast, Viagra, made by Pfizer Inc., is much cheaper.